Calpain inhibition prevents pacing-induced cellular remodeling in a HL-1 myocyte model for atrial fibrillation.

@article{Brundel2004CalpainIP,
  title={Calpain inhibition prevents pacing-induced cellular remodeling in a HL-1 myocyte model for atrial fibrillation.},
  author={Bianca J. J. M. Brundel and Harm H. Kampinga and Robert H. Henning},
  journal={Cardiovascular research},
  year={2004},
  volume={62 3},
  pages={521-8}
}
OBJECTIVE Atrial fibrillation (AF) is a progressive disease. Previously, clinical and animal experimental studies in AF revealed a variety of myocyte remodeling processes including L-type Ca(2+) channel reduction and structural changes, which finally result in electrical remodeling and contractile dysfunction. There are indications that myocyte remodeling is mediated by Ca(2+) overload induced calpain activation. To study in more detail the mechanisms underlying myocyte remodeling and to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Functional consequences of caspase activation in cardiac myocytes

  • C Communal, M Sumandea, P De Tombe
  • Proc Natl Acad Sci U S A 2002;99:6252–6
  • 2004
2 Excerpts

Molecular mechanisms of early electrical remodeling: transcriptional downregulation of ion-channel subunits reduces ICaL and Ito in rapid atrial pacing in rabbits

  • RF Bosch, CR Scherer, N Rüb
  • J Am Coll Cardiol 2003;41:858–69
  • 2003
2 Excerpts

Similar Papers

Loading similar papers…