Calpain inhibition attenuates angiotensin II-induced abdominal aortic aneurysms and atherosclerosis in low-density lipoprotein receptor-deficient mice.

Abstract

Chronic infusion of angiotensin II (AngII) augments atherosclerosis and abdominal aortic aneurysm (AAA) formation in hypercholesterolemic mice. AngII-induced AAAs are associated with medial macrophage accumulation and matrix metalloproteinase (MMP) activation. Inhibition of calpain, a calcium-activated neutral cysteine protease, by overexpression of its… (More)
DOI: 10.1097/FJC.0b013e318235d5ea

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@article{Subramanian2012CalpainIA, title={Calpain inhibition attenuates angiotensin II-induced abdominal aortic aneurysms and atherosclerosis in low-density lipoprotein receptor-deficient mice.}, author={Venkateswaran Subramanian and Haruhito Adam Uchida and Talha Ijaz and Jessica J. Moorleghen and Deborah A. Howatt and Anju Balakrishnan}, journal={Journal of cardiovascular pharmacology}, year={2012}, volume={59 1}, pages={66-76} }