Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax.

@article{Toyota2003CalpaininducedBP,
  title={Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax.},
  author={Hiroko Toyota and Noriko Yanase and Takayuki Yoshimoto and Masami Moriyama and Tetsuo Sudo and Junichiro Mizuguchi},
  journal={Cancer letters},
  year={2003},
  volume={189 2},
  pages={221-30}
}
Wild type (wt) p21 Bax was cleaved to generate p18 Bax during apoptotic processes by calpain, which was suggested to recognize a certain motif around amino acids 30-33 Phe-Ile-Gln-Asp (FIQD). In the present study, analysis of protein sequencing revealed that the cleavage site was between Gln28 and Gly29. The fragment lacking the NH(2)-terminal amino acids 1-28 (tBax(29)) was more apoptotic than wt Bax. The tBax(29)-induced apoptotic cell death was substantially resistant to Bcl-x(L)-mediated… CONTINUE READING

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