Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation.

@article{Dufty2007CalpaincleavageOA,
  title={Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation.},
  author={Brian M Dufty and Lisa R. Warner and Sheng T Hou and Susan X Jiang and Teresa G{\'o}mez-Isla and Kristen M Leenhouts and Julia Thom Oxford and Mel B. Feany and Eliezer Masliah and Troy T. Rohn},
  journal={The American journal of pathology},
  year={2007},
  volume={170 5},
  pages={1725-38}
}
Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are both characterized pathologically by the presence of neuronal inclusions termed Lewy bodies (LBs). A common feature found in LBs are aggregates of alpha-synuclein (alpha-Syn), and although it is now recognized that alpha-Syn is the major building block for these toxic filaments, the mechanism of how this occurs remains unknown. In the present study, we demonstrate that proteolytic processing of alpha-Syn by the protease calpain I… CONTINUE READING

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