Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer’s disease

@inproceedings{Atherton2014CalpainCA,
  title={Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer’s disease},
  author={Joe Atherton and Ksenia Kurbatskaya and Marie K. Bondulich and Cara L Croft and Claire J Garwood and Resham Chhabra and Selina Wray and Andreas Jeromin and Diane P Hanger and Wendy Noble},
  booktitle={Aging cell},
  year={2014}
}
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by pathological deposits of β-amyloid (Aβ) in senile plaques, intracellular neurofibrillary tangles (NFTs) comprising hyperphosphorylated aggregated tau, synaptic dysfunction and neuronal death. Substantial evidence indicates that disrupted neuronal calcium homeostasis is an early event in AD that could mediate synaptic dysfunction and neuronal toxicity. Sodium calcium exchangers (NCXs) play important roles in regulating… CONTINUE READING
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Towards Understanding the Role of the Na²⁺-Ca²⁺ Exchanger Isoform 3.

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