Calpain and caspase: can you tell the difference?

@article{Wang2000CalpainAC,
  title={Calpain and caspase: can you tell the difference?},
  author={K. Wang},
  journal={Trends in Neurosciences},
  year={2000},
  volume={23},
  pages={20-26}
}
  • K. Wang
  • Published 2000
  • Medicine, Biology
  • Trends in Neurosciences
Both necrotic and apoptotic neuronal death are observed in various neurological and neurodegenerative disorders. Calpain is activated in various necrotic and apoptotic conditions, while caspase 3 is only activated in neuronal apoptosis. Despite the difference in cleavage-site specificity, an increasing number of cellular proteins are found to be dually susceptible to these cysteine proteases. These include alpha- and beta-fodrin, calmodulin-dependent protein kinases, ADP-ribosyltransferase… Expand
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936 Citations

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  • J. Newcomb-Fernandez, X. Zhao, +5 authors R. Hayes
  • Biology, Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2001
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Multiple alphaII-spectrin breakdown products distinguish calpain and caspase dominated necrotic and apoptotic cell death pathways
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References

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