Calpain and caspase: can you tell the difference?

@article{Wang2000CalpainAC,
  title={Calpain and caspase: can you tell the difference?},
  author={K. Wang},
  journal={Trends in Neurosciences},
  year={2000},
  volume={23},
  pages={20-26}
}
  • K. Wang
  • Published 2000
  • Medicine, Biology
  • Trends in Neurosciences
Both necrotic and apoptotic neuronal death are observed in various neurological and neurodegenerative disorders. Calpain is activated in various necrotic and apoptotic conditions, while caspase 3 is only activated in neuronal apoptosis. Despite the difference in cleavage-site specificity, an increasing number of cellular proteins are found to be dually susceptible to these cysteine proteases. These include alpha- and beta-fodrin, calmodulin-dependent protein kinases, ADP-ribosyltransferase… Expand
936 Citations
Cleaved Fragments Prediction Algorithm (CFPA) application to calpain and caspase in apoptosis and necrotic cell death
Calpain Facilitates the Neuron Death Induced by 3‐Nitropropionic Acid and Contributes to the Necrotic Morphology
Implication of calpain in neuronal apoptosis
Involvement of caspases and calpains in cerebrocortical neuronal cell death is stimulus‐dependent
Concurrent Assessment of Calpain and Caspase-3 Activation after Oxygen–Glucose Deprivation in Primary Septo-Hippocampal Cultures
  • J. Newcomb-Fernandez, X. Zhao, +5 authors R. Hayes
  • Biology, Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2001
In Vivo Calpain/Caspase Cross-talk during 3-Nitropropionic Acid-induced Striatal Degeneration
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 86 REFERENCES
Cleavage of the calpain inhibitor, calpastatin, during apoptosis
Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis.
Conversion of Bcl-2 to a Bax-like death effector by caspases.
Calpain activation in apoptosis
...
1
2
3
4
5
...