Calpain and calpastatin in myoblast differentiation and fusion: effects of inhibitors.

@article{Barnoy1997CalpainAC,
  title={Calpain and calpastatin in myoblast differentiation and fusion: effects of inhibitors.},
  author={Sivia Barnoy and Tova Glaser and Nechama S. Kosower},
  journal={Biochimica et biophysica acta},
  year={1997},
  volume={1358 2},
  pages={181-8}
}
Myoblast differentiation and fusion to multinucleated muscle cells can be studied in myoblasts grown in culture. Calpain (Ca(2+)-activated thiol protease) induced proteolysis has been suggested to play a role in myoblast fusion. We previously showed that calpastatin (the endogenous inhibitor of calpain) plays a role in cell membrane fusion. Using the red cell as a model, we found that red cell fusion required calpain activation and that fusibility depended on the ratio of cell calpain to… CONTINUE READING
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