Calpain and N-methyl-d-aspartate (NMDA)-induced excitotoxicity in rat retinas.

  title={Calpain and N-methyl-d-aspartate (NMDA)-induced excitotoxicity in rat retinas.},
  author={K W K Chiu and Tim Tak Lam and Winnie Wai Ying Li and Joseph Caprioli and Jacky Man Kwong Kwong},
  journal={Brain research},
  volume={1046 1-2},
Calpain-mediated proteolysis has been implicated as a major process in neuronal cell death in both acute insults and the chronic neurodegenerative disorders in the central nerves system. However, activation of calpain also plays a protective function in the early phase of excitotoxic neuronal death. The exact role of calpains in neuronal death and recovery after exposure to N-methyl-D-aspartate (NMDA) is not clearly known. The purpose of present study was to examine the involvement of mu- and m… CONTINUE READING
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