Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus.

@article{Arajo2008CalpainAI,
  title={Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus.},
  author={In{\^e}s Ara{\'u}jo and Joana M. A. C. Gil and Bruno Pereira Carreira and Paul Mohapel and {\AA} Peters{\'e}n and Paulo S. Pinheiro and Denis Soulet and Ben A Bahr and Patrik Brundin and Caetana Monteiro Carvalho},
  journal={Journal of neurochemistry},
  year={2008},
  volume={105 3},
  pages={666-76}
}
Evidence for increased calpain activity has been described in the hippocampus of rodent models of temporal lobe epilepsy. However, it is not known whether calpains are involved in the cell death that accompanies seizures. In this work, we characterized calpain activation by examining the proteolysis of calpain substrates and in parallel we followed cell death in the hippocampus of epileptic rats. Male Wistar rats were injected with kainic acid (10 mg/kg) intraperitoneally and killed 24 h later… CONTINUE READING

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