Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2

@article{Adamec2002CalpainAI,
  title={Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2},
  author={Emil Adamec and Panaiyur Mohan and Jean Paul G. Vonsattel and Ralph A. Nixon},
  journal={Acta Neuropathologica},
  year={2002},
  volume={104},
  pages={92-104}
}
The calcium-activated protease calpain cleaves a variety of biologically important proteins and serves, therefore, as a key regulator of many cellular functions. Activation of both main isoforms, calpain 1 and calpain 2, was demonstrated previously in Alzheimer's disease. In this report, antibodies specifically recognizing the active form of calpain 2 were used to investigate calpain 2 activation in a broad range of neurodegenerative diseases, utilizing multiple-label confocal… CONTINUE READING

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