Calpain-I induced alterations in the cytoskeletal structure and impaired mechanical properties of single myocytes of rat heart.

@article{Papp2000CalpainIIA,
  title={Calpain-I induced alterations in the cytoskeletal structure and impaired mechanical properties of single myocytes of rat heart.},
  author={Zsuzsanna Papp and Jolanda van der Velden and Ger J M Stienen},
  journal={Cardiovascular research},
  year={2000},
  volume={45 4},
  pages={
          981-93
        }
}
OBJECTIVE The involvement of Calpain-I mediated proteolysis has been implicated in myofibrillar dysfunction of reperfused myocardium following ischemia (stunning). This study addresses the question whether ultrastructural alterations might be responsible for the depressed contractility. METHODS Mechanical properties and protein composition of isolated myocytes after Calpain-I exposure (1.25 U/ml; 10 min; 15 degrees C; pCa 5.0) and of ischemic rat hearts following reperfusion were… CONTINUE READING
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