Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage.

@article{Siman1989CalpainIA,
  title={Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage.},
  author={Robert A Siman and J C Noszek and C Kegerise},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1989},
  volume={9 5},
  pages={1579-90}
}
Sustained stimulation of receptors for excitatory amino acids leads to both activation of the calcium-dependent cysteine protease calpain I and to the death of receptive neurons. Here, we have examined the relationship between the calpain I activation and neurodegeneration. Calpain I activation was manifested as increased levels of the major proteolytic fragments of the calpain substrate spectrin, detected and quantified by immunoblotting. Intraventricular administration of the excitatory amino… CONTINUE READING