Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages.

@article{Vaelimaeki2016CalpainAI,
  title={Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages.},
  author={Elina Vaelimaeki and Wojciech Cypryk and Juhani Virkanen and Katariina Nurmi and Pauli M Turunen and Kari K Eklund and Karl E {\AA}kerman and Tuula A. Nyman and Sampsa Matikainen},
  journal={Journal of immunology},
  year={2016},
  volume={197 8},
  pages={
          3315-3325
        }
}
Extracellular ATP is an endogenous danger signal that is known to activate inflammatory responses in innate immune cells, including macrophages. Activated macrophages start to secrete proteins to induce an immune response, as well as to recruit other immune cells to the site of infection and tissue damage. In this study, we characterized the secretome (i.e., the global pattern of secreted proteins) of ATP-stimulated human macrophages. We show that ATP stimulation activates robust vesicle… CONTINUE READING

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