Calpain-6 Deficiency Promotes Skeletal Muscle Development and Regeneration

  title={Calpain-6 Deficiency Promotes Skeletal Muscle Development and Regeneration},
  author={Kazuo Tonami and Shoji Hata and Koichi Ojima and Yasuko Ono and Yukiko Kurihara and Tomokazu Amano and Takahiro Sato and Yumiko Kawamura and Hiroki Kurihara and Hiroyuki Sorimachi},
  booktitle={PLoS genetics},
Calpains are Ca(2+)-dependent modulator Cys proteases that have a variety of functions in almost all eukaryotes. There are more than 10 well-conserved mammalian calpains, among which eutherian calpain-6 (CAPN6) is unique in that it has amino acid substitutions at the active-site Cys residue (to Lys in humans), strongly suggesting a loss of proteolytic activity. CAPN6 is expressed predominantly in embryonic muscles, placenta, and several cultured cell lines. We previously reported that CAPN6 is… CONTINUE READING
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Calpain chronicle—an enzyme family under multidisciplinary characterization

Proceedings of the Japan Academy. Series B, Physical and biological sciences • 2011
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