Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis.

@article{Altznauer2004Calpain1RB,
  title={Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis.},
  author={Frank Altznauer and S{\'e}bastien Conus and Andrea Cavalli and Gerd Folkers and H. -U. Simon},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 7},
  pages={5947-57}
}
In the absence and in the resolution of inflammatory responses, neutrophils rapidly undergo spontaneous apoptosis. Here we report about a new apoptosis pathway in these cells that requires calpain-1 activation and is essential for the enzymatic activation of the critical effector caspase-3. Decreased levels of calpastatin, a highly specific intrinsic inhibitor of calpain, resulted in activation of calpain-1, but not calpain-2, in neutrophils undergoing apoptosis, a process that was blocked by a… CONTINUE READING
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