Calpain-1 inhibitors for selective treatment of rheumatoid arthritis: what is the future?

Abstract

Effective small-molecule treatment of inflammatory diseases remains an unmet need in medicine. Current treatments are either limited in effectiveness or invasive. The latest biologics prevent influx of inflammatory cells to damaged tissue. Calpain-1 is a calcium-activated cysteine protease that plays an important role in neutrophil motility. It is… (More)
DOI: 10.4155/fmc.13.172

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