Calpain 1-gamma filamin interaction in muscle cells: a possible in situ regulation by PKC-alpha.

@article{Raynaud2006Calpain1F,
  title={Calpain 1-gamma filamin interaction in muscle cells: a possible in situ regulation by PKC-alpha.},
  author={Fabrice Raynaud and Carole Jond-Necand and Anne Marcilhac and Dieter O. F{\"u}rst and Yves Benyamin},
  journal={The international journal of biochemistry & cell biology},
  year={2006},
  volume={38 3},
  pages={
          404-13
        }
}
Calpains are a family of calcium-dependent cysteine-proteases involved in cytoskeleton remodelling and muscle differentiation. In a recent study, we observed the presence of calpain 1 in the muscle contractile apparatus and specifically in the N1- and N2-lines. This calpain isoform was found to be involved in the degradation of muscle fibres via proteolysis of key proteins in Z-disk and costameric junctions. The goal of this study was to determine whether gamma-filamin--a specific muscle… CONTINUE READING

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