Calpain (Ca(2+)-dependent thiol protease) in erythrocytes of young and old individuals.

@article{Glaser1994CalpainT,
  title={Calpain (Ca(2+)-dependent thiol protease) in erythrocytes of young and old individuals.},
  author={Tova Glaser and N Schwarz-Benmeir and Sivia Barnoy and Shai Barak and Zelig Eshhar and Nechama S. Kosower},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 17},
  pages={
          7879-83
        }
}
Limited proteolysis by calpain (Ca(2+)-activated protease; EC 3.4.22.17) is believed to regulate the function of membrane enzymes and modify the behavior of membrane structural proteins. Calpain is activated by autolysis. The degradation of band 3 protein by mu-calpain is known to be enhanced in erythrocyte membranes from human individuals > 70 years old (old) as compared with that from individuals 20-30 years old (young). In the present study, monoclonal antibody to mu-calpain was used to… CONTINUE READING
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