Caloxin: a novel plasma membrane Ca2+ pump inhibitor.

@article{Chaudhary2001CaloxinAN,
  title={Caloxin: a novel plasma membrane Ca2+ pump inhibitor.},
  author={Jagadanand Chaudhary and Mandeep Walia and Jagjit Singh Matharu and Emanuel Escher and A. K. Grover},
  journal={American journal of physiology. Cell physiology},
  year={2001},
  volume={280 4},
  pages={
          C1027-30
        }
}
Plasma membrane (PM) Ca2+ pump is a Ca+-Mg2+-ATPase that expels Ca2+ from cells to help them maintain low concentrations of cytosolic Ca2+ . There are no known extracellularly acting PM Ca2+ pump inhibitors, as digoxin and ouabain are for Na+ pump. In analogy with digoxin, we define caloxins as extracellular PM Ca2+ pump inhibitors and describe caloxin 2A1. Caloxin 2A1 is a peptide obtained by screening a random peptide phage display library for binding to the second extracellular domain… CONTINUE READING
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