Calorimetry and thermodynamics in drug design.

  title={Calorimetry and thermodynamics in drug design.},
  author={Jonathan B. Chaires},
  journal={Annual review of biophysics},
Modern instrumentation for calorimetry permits direct determination of enthalpy values for binding reactions and conformational transitions in biomolecules. Complete thermodynamic profiles consisting of free energy, enthalpy, and entropy may be obtained for reactions of interest in a relatively straightforward manner. Such profiles are of enormous value in drug design because they provide information about the balance of driving forces that cannot be obtained from structural or computational… CONTINUE READING

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