Calorimetric studies of melanotransferrin (p97) and its interaction with iron.

  title={Calorimetric studies of melanotransferrin (p97) and its interaction with iron.},
  author={A. Louise Creagh and Jacqueline W C Tiong and Mei Mei Tian and Charles A. Haynes and Wilfred A Jefferies},
  journal={The Journal of biological chemistry},
  volume={280 16},
The mammalian molecule melanotransferrin (mTf), also called p97, is a member of the transferrin family of molecules. It exists in both secreted and glycosylphosphatidylinositol-anchored forms and is thought to play a role in angiogenesis and in transporting iron across the blood brain barrier. The binding affinity of iron to this molecule has not been formally established. Here, the binding of ferric ion (chelated with a 2-fold molar ratio of nitrilotriacetate) to mTf has been studied using… CONTINUE READING


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