Calorie restriction protects against age‐related rat aorta sclerosis

@article{Castello2005CalorieRP,
  title={Calorie restriction protects against age‐related rat aorta sclerosis},
  author={Laura Castello and Teresa Froio and Gabriella Cavallini and Fiorella Biasi and Anna Sapino and Gabriella Leonarduzzi and Ettore Bergamini and Giuseppe Poli and Elena Chiarpotto},
  journal={The FASEB Journal},
  year={2005},
  volume={19}
}
Many theories have been advanced to account for the ageing process, among which the free radical theory deserves much attention. Numerous studies have also shown an association between tissue fibrosis and oxidative stress. Of note, fibrosis may be considered a significant index of tissue ageing. Calorie restriction (CR) has been demonstrated to maintain many physiological processes in a youthful state until a very advanced age. However the anti‐ageing mechanisms of CR are still not fully… 
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Reversal of altered iNOS/eNOS ratio, reduced oxidative stress and increased SOD enzyme activity rather than enhanced NO production appear to be involved in this effect.
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The theme that emerges from this overview is that neuroendocrine factors induced by caloric restriction attenuate age-related reactive oxygen species (ROS) overproduction and prevent inflammatory phenotypic alterations in the cardiovascular system.
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