Calorie restriction mimetics: an emerging research field

@article{Ingram2006CalorieRM,
  title={Calorie restriction mimetics: an emerging research field},
  author={Donald K Ingram and Min Zhu and Jacek Mamczarz and Sige Zou and Mark A. Lane and George S. Roth and Rafael Decabo},
  journal={Aging Cell},
  year={2006},
  volume={5}
}
When considering all possible aging interventions evaluated to date, it is clear that calorie restriction (CR) remains the most robust. Studies in numerous species have demonstrated that reduction of calories 30–50% below ad libitum levels of a nutritious diet can increase lifespan, reduce the incidence and delay the onset of age‐related diseases, improve stress resistance, and decelerate functional decline. A current major focus of this research area is whether this nutritional intervention is… 
View on Wiley
info-centre.jenage.de
383 Citations
Highly Influential Citations
7
Background Citations
142
Methods Citations
6
Results Citations
1

383 Citations

Citation Type

Citation Type

Newer antidiabetic drugs and calorie restriction mimicry
TLDR
This review focuses on the CR mimetic properties of the currently available anti-diabetic agents, some of which may have someCR mimetic like effects.
Development of Calorie Restriction Mimetics as Therapeutics for Obesity, Diabetes, Inflammatory and Neurodegenerative Diseases
TLDR
The target pathways, candidate molecules, and strategies to develop CR mimetics, a field of research focusing on the development of molecules that mimic the beneficial effects of CR without reducing food intake, are described.
Glycolytic inhibition as a strategy for developing calorie restriction mimetics
Calorie Restriction Mimetics: Progress and Potential
TLDR
This review will weigh the evidence that CRMs can replicate some, if not most, of the same positive biological effects, and attempt to offer as objective an evaluation as possible of the current status of CRMs, and the best opportunities to extend this strategy to human applications.
The Implications of Calorie Restriction on Longevity and Health Span
TLDR
Through investigation of epigenetics, the efficacy of calorie restriction is being examined to provide insight into its potential benefits, and alterations to metabolic pathways may also reveal a reduction in inflammation and oxidative stress, markers of aging-related disease.
Could calorie restriction increase longevity in humans
TLDR
There is a lot that can be learned from a handful of epidemiological and cross-sectional observations in longer-lived humans, centenarians and individuals who self-impose CR.
Calorie restriction mimetics: Can you have your cake and eat it, too?
Aging, Calorie Restriction and Calorie Restriction Mimetics
TLDR
This overview summarizes the latest data on known mechanisms of caloric restriction and more familiar caloric restriction mimetics.
Of mice and men: The benefits of caloric restriction, exercise, and mimetics
The use of calorie restriction mimetics to study aging.
TLDR
This chapter focuses on candidate CRMs including sirtuin-activating compounds (STACs) and mTOR inhibitors, their slowing of aging, and methods for evaluation of lifespan and metabolic disorders.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 150 REFERENCES
Development of Calorie Restriction Mimetics as a Prolongevity Strategy
Abstract: By applying calorie restriction (CR) at 30‐50% below ad libitum levels, studies in numerous species have reported increased life span, reduced incidence and delayed onset of age‐related…
Caloric restriction mimetics: metabolic interventions.
TLDR
Panel 2 focused on two outcomes of CR, reduction of oxidative stress and improved glucoregulation, for which candidate metabolic mimics exist, and recommended that studies on oxidative stress should emphasize mitochondrial function and to test the efficacy of nitrone and other antioxidants in mimicking CR's effects.
Caloric Restriction Mimetics
TLDR
A number of candidate CR mimetics including glycolytic inhibitors, antioxidants and specific gene-modulators have been investigated and appear to validate the potential of this approach.
Caloric Restriction Mimetics: The Next Phase
TLDR
The next phase of calorie restriction studies includes basic investigations as well as possible clinical trials of a number of candidate CR mimetics, ranging from glycolytic inhibitors to lipid‐regulating agents to antioxidants and specific gene modulators.
Human implications of caloric restriction's effects on aging in laboratory animals: an overview of opportunities for research.
TLDR
The Caloric Restriction Clinical Implications Advisory Group was convened to consider opportunities for such research and included expertise in gerontology, epidemiology, clinical trials, nutrition, metabolism, endocrinology, neuroendocrineology, genetics, pharmacology, and behavioral medicine.
Caloric Restriction in Primates
TLDR
Conclusive evidence showing that CR extends life span in primates is not presently available; however, the emerging data from the ongoing primate studies strengthens the possibility that the diverse beneficial effects of CR on aging in rodents will also apply to nonhuman primates and perhaps ultimately to humans.
Caloric Restriction in Primates and Relevance to Humans
TLDR
Results strongly suggest that the same beneficial “antiaging” and/or “antidisease” effects observed in CR rodents also occur in primates and suggest that CR primates will be less likely to incur diabetes, cardiovascular problems, and other age‐related diseases and may in fact be aging more slowly than fully fed counterparts.
Calorie restriction and aging: review of the literature and implications for studies in humans.
TLDR
The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans.
TLDR
This review synthesizes the key biological mechanisms underlying many of the beneficial effects of CR, with a particular focus on the insulin-like growth factor-1 pathway and some of the opportunities now available for investigations.
2-Deoxy-D-Glucose Feeding in Rats Mimics Physiologic Effects of Calorie Restriction
TLDR
Results from CR studies in rhesus monkeys agree with the extensive rodent literature that suggests this intervention can have beneficial effects in primates, and it is unlikely that the 30% to 40% reduction in intake used typically in this paradigm would become a widespread practice in humans.
...
1
2
3
4
5
...