Calorie restriction mimetics: Can you have your cake and eat it, too?

  title={Calorie restriction mimetics: Can you have your cake and eat it, too?},
  author={Donald K Ingram and George S. Roth},
  journal={Ageing Research Reviews},

Manipulation of health span and function by dietary caloric restriction mimetics

The current status of the field of CR mimetics is reviewed, with particular focus on recent developments, the most practical relevance and applicability for potential consumers, and new strategies for the future.

Calorie Restriction Mimetics: Progress and Potential

This review will weigh the evidence that CRMs can replicate some, if not most, of the same positive biological effects, and attempt to offer as objective an evaluation as possible of the current status of CRMs, and the best opportunities to extend this strategy to human applications.

Caloric Restriction Mimetics in Nutrition and Clinical Trials

Dietary sources, availability and intake levels of dietary Caloric Restriction Mimetics (CRMs), and a summary of their effects in clinical trials are discussed.

Energy restriction and potential energy restriction mimetics

Current scientific literature on ER and its molecular, metabolic and hormonal effects are discussed, and criteria for the classification of substances that might induce positive ER-like changes without having to reduce energy intake are summarised.

Caloric restriction mimetics: the next generation of anti-aging treatments

Several compounds that have emerged as potential caloric restriction mimetics inducing overlapping mechanisms to caloric restriction are described, including 2-deoxy-D-glucose (glycolytic inhibitor), Metformin (biguanide), Pegvisomant and Octreoside (IGF-1 antagonist), Resveratrol (SIRT-1 agonist) and Neuropeptide Y.

Diabetes medications as potential calorie restriction mimetics-a focus on the alpha-glucosidase inhibitor acarbose.

Acarbose, an AGI, has been shown in pre-clinical models to increase lifespan (greater longevity benefits in males), with decreased body weight gain independent of calorie intake reduction, and is supported by clinical findings beyond T2D including the risk for other age-related diseases.

Is there a role of H2S in mediating health span benefits of caloric restriction?

Caloric restriction and exercise "mimetics'': Ready for prime time?




Calorie restriction mimetics: an emerging research field

New research has focused on the development of ‘CR mimetics’, which is to identify compounds that mimic CR effects by targeting metabolic and stress response pathways affected by CR, but without actually restricting caloric intake.

Exercise as a calorie restriction mimetic: implications for improving healthy aging and longevity.

  • D. Huffman
  • Biology
    Interdisciplinary topics in gerontology
  • 2010
Like CR, exercise can limit weight gain and adiposity, but only CR can extend lifespan, and in rodents, the ability of CR to slow aging is apparently more dependent on decreasing nutrient flux, rather than changes in energy balance and body composition.

Caloric Restriction Mimetics: The Next Phase

The next phase of calorie restriction studies includes basic investigations as well as possible clinical trials of a number of candidate CR mimetics, ranging from glycolytic inhibitors to lipid‐regulating agents to antioxidants and specific gene modulators.

Caloric restriction mimetics: metabolic interventions.

Panel 2 focused on two outcomes of CR, reduction of oxidative stress and improved glucoregulation, for which candidate metabolic mimics exist, and recommended that studies on oxidative stress should emphasize mitochondrial function and to test the efficacy of nitrone and other antioxidants in mimicking CR's effects.

Development of Calorie Restriction Mimetics as a Prolongevity Strategy

Abstract: By applying calorie restriction (CR) at 30‐50% below ad libitum levels, studies in numerous species have reported increased life span, reduced incidence and delayed onset of age‐related

Overview of caloric restriction and ageing

  • E. Masoro
  • Biology
    Mechanisms of Ageing and Development
  • 2005

Caloric restriction in humans: Potential pitfalls and health concerns

Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans.

This review synthesizes the key biological mechanisms underlying many of the beneficial effects of CR, with a particular focus on the insulin-like growth factor-1 pathway and some of the opportunities now available for investigations.