Calorie restriction mimetics: Can you have your cake and eat it, too?

@article{Ingram2015CalorieRM,
  title={Calorie restriction mimetics: Can you have your cake and eat it, too?},
  author={Donald K. Ingram and George S. Roth},
  journal={Ageing Research Reviews},
  year={2015},
  volume={20},
  pages={46-62}
}
Strong consensus exists regarding the most robust environmental intervention for attenuating aging processes and increasing healthspan and lifespan: calorie restriction (CR). Over several decades, this paradigm has been replicated in numerous nonhuman models, and has been expanded over the last decade to formal, controlled human studies of CR. Given that long-term CR can create heavy challenges to compliance in human diets, the concept of a calorie restriction mimetic (CRM) has emerged as an… CONTINUE READING

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