Calorie restriction limits the generation but not the progression of mitochondrial abnormalities in aging skeletal muscle

@article{Bua2004CalorieRL,
  title={Calorie restriction limits the generation but not the progression of mitochondrial abnormalities in aging skeletal muscle},
  author={Entela Bua and Susan H. McKiernan and Judd M. Aiken},
  journal={The FASEB Journal},
  year={2004},
  volume={18}
}
The effect of early‐onset calorie restriction and aging on the accumulation of electron transport system (ETS) abnormalities was studied in rat skeletal muscle. Rectus femoris and vastus lateralis muscle fibers were analyzed for cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) enzyme activities. Fibers displaying COX negative and SDH hyper reactive (COX–/SDH++) phenotype were followed through 1000–2000 micrometers to determine the frequency and length of these abnormalities as well… 
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TLDR
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Age- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM binding
TLDR
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Aging and Calorie Restriction Oppositely Affect Mitochondrial Biogenesis through TFAM Binding at Both Origins of Mitochondrial DNA Replication in Rat Liver
TLDR
An age-related decrease in mitochondrial DNA content and mitochondrial transcription factor A amount was found and a marked increase in the TFAM-bound amounts of mtDNA at both origins of replication with aging, fully prevented by CR.
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