Calorie restriction limits the generation but not the progression of mitochondrial abnormalities in aging skeletal muscle

@article{Bua2004CalorieRL,
  title={Calorie restriction limits the generation but not the progression of mitochondrial abnormalities in aging skeletal muscle},
  author={Entela Bua and S. McKiernan and J. Aiken},
  journal={The FASEB Journal},
  year={2004},
  volume={18}
}
The effect of early‐onset calorie restriction and aging on the accumulation of electron transport system (ETS) abnormalities was studied in rat skeletal muscle. Rectus femoris and vastus lateralis muscle fibers were analyzed for cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) enzyme activities. Fibers displaying COX negative and SDH hyper reactive (COX–/SDH++) phenotype were followed through 1000–2000 micrometers to determine the frequency and length of these abnormalities as well… Expand
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