Calorie restriction in humans: An update.

  title={Calorie restriction in humans: An update.},
  author={Jasper Most and Valeria Tosti and Leanne Maree Redman and Edward Saltzman},
  journal={Ageing research reviews},
Calorie restriction (CR), a nutritional intervention of reduced energy intake but with adequate nutrition, has been shown to extend healthspan and lifespan in rodent and primate models. Accumulating data from observational and randomized clinical trials indicate that CR in humans results in some of the same metabolic and molecular adaptations that have been shown to improve health and retard the accumulation of molecular damage in animal models of longevity. In particular, moderate CR in humans… CONTINUE READING
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