Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

  title={Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration},
  author={S J Lin and Matt Kaeberlein and Alex A. Andalis and Lori A. Sturtz and P -A Defossez and Valeria C Culotta and Gerald Fink and Leonard P. Guarente},
Calorie restriction (CR) extends lifespan in a wide spectrum of organisms and is the only regimen known to lengthen the lifespan of mammals. We established a model of CR in budding yeast Saccharomyces cerevisiae. In this system, lifespan can be extended by limiting glucose or by reducing the activity of the glucose-sensing cyclic-AMP-dependent kinase (PKA). Lifespan extension in a mutant with reduced PKA activity requires Sir2 and NAD (nicotinamide adenine dinucleotide). In this study we… CONTINUE READING
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