Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney.

@article{Kume2010CalorieRE,
  title={Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney.},
  author={Shinji Kume and Takashi Uzu and Kihachiro Horiike and Masami Chin-Kanasaki and Keiji Isshiki and Shin-Ichi Araki and Tsuneaki Sugimoto and Masakazu Haneda and Atsunori Kashiwagi and Daisuke Koya},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 4},
  pages={
          1043-55
        }
}
Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies demonstrate that this process is attenuated by calorie restriction (CR). However, the molecular mechanism that underlies the beneficial effect of CR on mitochondrial dysfunction is unclear. Here, we investigated in mice the mechanisms underlying CR-mediated protection against hypoxia in aged kidney, with a special focus on the role of the NAD-dependent deacetylase sirtuin 1 (Sirt1), which is linked to CR-related… CONTINUE READING

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