Calorie restriction enhances T-cell-mediated immune response in adult overweight men and women.

@article{Ahmed2009CalorieRE,
  title={Calorie restriction enhances T-cell-mediated immune response in adult overweight men and women.},
  author={Tanvir Ahmed and Sai Krupa Das and Julie K Golden and Edward Saltzman and Susan B Roberts and Simin Nikbin Meydani},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2009},
  volume={64 11},
  pages={1107-13}
}
Calorie restriction (CR) enhances immune response and prolongs life span in animals. However, information on the applicability of these results to humans is limited. T-cell function declines with age. We examined effects of CR on T-cell function in humans. Forty-six overweight, nonobese participants aged 20-42 years were randomly assigned to 30% or 10% CR group for 6 months. Delayed-type hypersensitivity (DTH), T-cell proliferation (TP), and prostaglandin E(2) (PGE(2)) productions were… CONTINUE READING

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