Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver

@article{Cabo2004CalorieRA,
  title={Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver},
  author={Rafael de Cabo and R. Cabello and Murcia R{\'i}os and Guillermo L{\'o}pez-Lluch and Placido Navas},
  journal={Experimental Gerontology},
  year={2004},
  volume={39},
  pages={297-304}
}
Aging is associated with increased production of reactive oxygen species and oxidation-induced damage to intracellular structures and membranes. Caloric restriction (CR) is the only non-genetic method proven to extend lifespan in mammals. Although the mechanisms of CR remain to be clearly elucidated, reductions in oxidative stress have been shown to increase lifespan in several model systems. Oxidative stress can be attenuated by CR. Mitochondria and plasma membrane (PM) are normal sources of… CONTINUE READING

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