Calorie-restricted weight loss reverses high-fat diet-induced ghrelin resistance, which contributes to rebound weight gain in a ghrelin-dependent manner.

@article{Briggs2013CalorierestrictedWL,
  title={Calorie-restricted weight loss reverses high-fat diet-induced ghrelin resistance, which contributes to rebound weight gain in a ghrelin-dependent manner.},
  author={Dana I Briggs and Sarah Haas Lockie and Qunli Wu and Moyra B Lemus and Romana Stark and Zane B Andrews},
  journal={Endocrinology},
  year={2013},
  volume={154 2},
  pages={709-17}
}
Twelve weeks of high-fat diet feeding causes ghrelin resistance in arcuate neuropeptide Y (NPY)/agouti-related protein (AgRP) neurons. In the current study, we investigated whether diet-induced weight loss could restore NPY/AgRP neuronal responsiveness to ghrelin and whether ghrelin mediates rebound weight gain after calorie-restricted (CR) weight loss. Diet-induced obese (DIO) mice were allocated to one of two dietary interventions until they reached the weight of age-matched lean controls… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 23 times over the past 90 days. VIEW TWEETS