Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures

  title={Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures},
  author={Marissa J. Schafer and Igor Dolgalev and Melissa J. Alldred and Adriana Heguy and Stephen D Ginsberg and Rozalyn M. Anderson},
  booktitle={PloS one},
Calorie restriction (CR) enhances longevity and mitigates aging phenotypes in numerous species. Physiological responses to CR are cell-type specific and variable throughout the lifespan. However, the mosaic of molecular changes responsible for CR benefits remains unclear, particularly in brain regions susceptible to deterioration during aging. We examined the influence of long-term CR on the CA1 hippocampal region, a key learning and memory brain area that is vulnerable to age-related… CONTINUE READING
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Altered calciummetabolism in aging CA1 hippocampal pyramidal neurons

  • OhMM, FA Oliveira, J Waters, JF Disterhoft
  • J Neurosci
  • 2013
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