Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase

@article{Cohen2004CalorieRP,
  title={Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase},
  author={H. Cohen and C. Miller and Kevin J. Bitterman and N. Wall and B. Hekking and B. Kessler and K. Howitz and M. Gorospe and R. de Cabo and D. Sinclair},
  journal={Science},
  year={2004},
  volume={305},
  pages={390 - 392}
}
  • H. Cohen, C. Miller, +7 authors D. Sinclair
  • Published 2004
  • Medicine, Biology
  • Science
  • A major cause of aging is thought to result from the cumulative effects of cell loss over time. In yeast, caloric restriction (CR) delays aging by activating the Sir2 deacetylase. Here we show that expression of mammalian Sir2 (SIRT1) is induced in CR rats as well as in human cells that are treated with serum from these animals. Insulin and insulin-like growth factor 1 (IGF-1) attenuated this response. SIRT1 deacetylates the DNA repair factor Ku70, causing it to sequester the proapoptotic… CONTINUE READING
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