Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase

@article{Cohen2004CalorieRP,
  title={Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase},
  author={Haim Y Cohen and Christine Miller and Kevin J. Bitterman and Nathan R. Wall and Brian G Hekking and Benedikt M. Kessler and Konrad T. Howitz and Myriam Gorospe and Rafael de Cabo and David A. Sinclair},
  journal={Science},
  year={2004},
  volume={305},
  pages={390 - 392}
}
A major cause of aging is thought to result from the cumulative effects of cell loss over time. In yeast, caloric restriction (CR) delays aging by activating the Sir2 deacetylase. Here we show that expression of mammalian Sir2 (SIRT1) is induced in CR rats as well as in human cells that are treated with serum from these animals. Insulin and insulin-like growth factor 1 (IGF-1) attenuated this response. SIRT1 deacetylates the DNA repair factor Ku70, causing it to sequester the proapoptotic… Expand
Tissue-specific regulation of SIRT 1 by calorie restriction
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