Calorie Restriction Hysteretically Primes Aging Saccharomyces cerevisiae toward More Effective Oxidative Metabolism

@inproceedings{Tahara2013CalorieRH,
  title={Calorie Restriction Hysteretically Primes Aging Saccharomyces cerevisiae toward More Effective Oxidative Metabolism},
  author={Erich Birelli Tahara and Fernanda F M Cunha and Thiago O. Basso and Bianca E. Della Bianca and Andreas K. Gombert and Alicia J Kowaltowski},
  booktitle={PloS one},
  year={2013}
}
Calorie restriction (CR) is an intervention known to extend the lifespan of a wide variety of organisms. In S. cerevisiae, chronological lifespan is prolonged by decreasing glucose availability in the culture media, a model for CR. The mechanism has been proposed to involve an increase in the oxidative (versus fermentative) metabolism of glucose. Here, we measured wild-type and respiratory incompetent (ρ(0)) S. cerevisiae biomass formation, pH, oxygen and glucose consumption, and the evolution… CONTINUE READING