Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice.

@article{Leeuwenburgh1997CaloricRA,
  title={Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice.},
  author={Christiaan Leeuwenburgh and P. R. S. Wagner and John O. Holloszy and Rajindar S. Sohal and Jay W. Heinecke},
  journal={Archives of biochemistry and biophysics},
  year={1997},
  volume={346 1},
  pages={
          74-80
        }
}
Oxidative damage, particularly to proteins, has been widely postulated to be a major causative factor in the loss of functional capacity during senescence. The nature of the various mechanisms that may contribute to protein oxidation is only partially understood. In this study, concentrations of two markers for oxidative damage, o,o'-dityrosine and o-tyrosine, were determined using stable isotope dilution gas chromatography-mass spectrometry in four tissues of the mouse, namely heart, skeletal… CONTINUE READING

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