Caloric restriction-associated remodeling of rat white adipose tissue: effects on the growth hormone/insulin-like growth factor-1 axis, sterol regulatory element binding protein-1, and macrophage infiltration

@article{Chujo2012CaloricRR,
  title={Caloric restriction-associated remodeling of rat white adipose tissue: effects on the growth hormone/insulin-like growth factor-1 axis, sterol regulatory element binding protein-1, and macrophage infiltration},
  author={Yoshikazu Chujo and Namiki Fujii and Naoyuki Okita and Tomokazu Konishi and Takumi Narita and Atsushi Yamada and Yushi Haruyama and Kousuke Tashiro and Takuya Chiba and Isao Shimokawa and Yoshikazu Higami},
  journal={AGE},
  year={2012},
  volume={35},
  pages={1143-1156}
}
The role of the growth hormone (GH)-insulin-like growth factor (IGF)-1 axis in the lifelong caloric restriction (CR)-associated remodeling of white adipose tissue (WAT), adipocyte size, and gene expression profiles was explored in this study. We analyzed the WAT morphology of 6–7-month-old wild-type Wistar rats fed ad libitum (WdAL) or subjected to CR (WdCR), and of heterozygous transgenic dwarf rats bearing an anti-sense GH transgene fed ad libitum (TgAL) or subjected to CR (TgCR). Although… CONTINUE READING

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