Caloric restriction as a mechanism mediating resistance to environmental disease.

  title={Caloric restriction as a mechanism mediating resistance to environmental disease.},
  author={Linda Frame and Ronald W. Hart and Julian E. A. Leakey},
  journal={Environmental Health Perspectives},
  pages={313 - 324}
It has been observed that susceptibility to many degenerative diseases increases concurrently with industrialization and rising living standards. Although epidemiologic studies suggest that specific environmental and dietary factors may be important, caloric intake alone (as reflected in body size) may account for much of the differential risk observed among diverse human populations. It has been suggested from animal studies that caloric intake may be the primary effector for many hormonal… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 29 extracted citations


Publications referenced by this paper.
Showing 1-10 of 199 references

Effects of caloric restriction on expression of testicular cytochrome P 450 enzymes associated with the metabolic activation of carcinogens

  • L Johnson, MR May, DL Busbee, JD Williams
  • Arch Biochem Biophys
  • 1996

Induction of the alkyltrans - ferase ( MGMT ) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes

  • J Bauer, TA Tran-Thi, +4 authors PC Heinrich
  • Carcinogenesis
  • 1996

Similar Papers

Loading similar papers…