Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats

  title={Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats},
  author={Donald E. Mager and Ruiqian Wan and Martin Brown and Aiwu Cheng and Przemyslaw Warȩski and Darrell R. Abernethy and Mark P. Mattson},
  journal={The FASEB Journal},
  pages={631 - 637}
Dietary restriction (DR) has been shown to increase life span, delay or prevent age‐associated diseases, and improve functional and metabolic cardiovascular risk factors in rodents and other species. To investigate the effects of DR on beat‐to‐beat heart rate and diastolic blood pressure variability (HRV and DPV) in male Sprague‐Dawley rats, we implanted telemetric transmitters and animals were maintained on either intermittent fasting (every other day feeding) or calorie‐restricted (40… 

Caloric Restriction and Its Effect on Blood Pressure, Heart Rate Variability and Arterial Stiffness and Dilatation: A Review of the Evidence

Caloric restriction appears to be effective regardless of age, gender, ethnicity, weight, body mass index (BMI) or a diagnosis of metabolic syndrome or type 2 diabetes, but the greatest benefit is usually observed in the sickest subjects and BP may continue to improve during the refeeding period.

Caloric restriction may reverse age‐related autonomic decline in humans

Evidence is provided that CR has direct systemic effects that counter the expected age‐associated changes in autonomic function so that HRV indexes in CR individuals are similar to those of individuals 20 years younger eating WDs.

Effects of calorie restriction on cardioprotection and cardiovascular health.

Caloric restriction reduces sympathetic activity similar to beta-blockers but conveys additional mitochondrio-protective effects in aged myocardium

Increased activation of sympathetic nervous system contributes to congestive heart failure (CHF) progression, and inhibition of sympathetic overactivation by beta-blockers is successful in CHF

Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice

It is demonstrated that TRF protects the BP circadian rhythm in db/db mice via suppressing the sympathetic activity during the light phase when they are inactive and fasting, and potentially pivotal role of the timing of food intake in the prevention and treatment of nondipping BP in diabetes is revealed.

Assessment of enhanced endothelium-dependent vasodilation by intermittent fasting in Wistar albino rats.

Intermittent fasting reduces weight gain in young male rats and improves their aortic endothelium-dependent vasorelaxation, a type of feeding regimen where the frequency of eating is reduced enhances cardiovascular stress adaptation and improves cardiovascular risk factors in rats.

Effects of Caloric Restriction Diet on Arterial Hypertension and Endothelial Dysfunction

Caloric restriction diet is able to counteract aging and delay the onset of CV and neurodegenerative diseases through the reduction of body fat mass, systolic and diastolic values, free radicals production, and oxidative stress.

Assessment of training effects on autonomic modulation of the cardiovascular system in mature rats using power spectral analysis of heart rate variability

  • T. Kumae
  • Biology
    Environmental Health and Preventive Medicine
  • 2012
The results in the Voluntary and the Forced groups suggest that cardiovascular adjustments are not simply caused by the quantity of exercise, and both sympathetic and parasympathetic activity may decrease with a predominance of sympathetic activity.



Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems.

Intermittent fasting and dietary supplementation with 2‐deoxy‐D‐glucose improve functional and metabolic cardiovascular risk factors in rats

Reductions in blood pressure, heart rate, and insulin levels, similar to or greater than those obtained with regular physical exercise programs, can be achieved by IF and by dietary supplementation with 2DG by a mechanism involving stress responses.

Long-term caloric restriction improves baroreflex sensitivity in aging Fischer 344 rats.

It is demonstrated that caloric restriction alters the age-associated decline in several hemodynamic parameters in rats which had been either ad libitum fed or calorie restricted.

Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

In conclusion, intermittent fasting resulted in beneficial effects that met or exceeded those of caloric restriction including reduced serum glucose and insulin levels and increased resistance of neurons in the brain to excitotoxic stress in these mice.

Autonomic nervous system and cardiovascular variability in rats: a spectral analysis approach.

It is concluded that the LF peak of DBP and the HF peak of HR are likely to represent useful estimates of the sympathetic vascular control and of the parasympathetic cardiac control, respectively.

Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism.

Alternate-day fasting was feasible in nonobese subjects, and fat oxidation increased, however, hunger on fasting days did not decrease, perhaps indicating the unlikelihood of continuing this diet for extended periods of time.

Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans.

It appears that long-term CR has a powerful protective effect against atherosclerosis, supported by the finding of a low carotid artery IMT.

Intermittent food deprivation improves cardiovascular and neuroendocrine responses to stress in rats.

Improvements in cardiovascular risk factors and cardiovascular and neuroendocrine stress adaptation occur in response to IF, and the IF treatment improved glucose metabolism, as indicated by lower basal levels of circulating glucose and insulin, but with maintenance of glucose and diabetes responses to stress.

Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor.

It is reported that an intermittent fasting DR regimen reverses several abnormal phenotypes of BDNF(+/-) mice including obesity, hyperphagia, and increased locomotor activity, which suggest that BDNF is a major regulator of energy metabolism and that beneficial effects of DR on glucose metabolism are mediated, in part, by BDNF signaling.