Caloric restriction, longevity and aging: Recent contributions from human and non-human primate studies

@article{Pifferi2019CaloricRL,
  title={Caloric restriction, longevity and aging: Recent contributions from human and non-human primate studies},
  author={Fabien Pifferi and Fabienne Aujard},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2019},
  volume={95}
}
  • F. Pifferi, F. Aujard
  • Published 2019
  • Medicine, Biology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
The health benefits of chronic caloric restriction (CR) resulting in lifespan extension are well established in many species and has been recently demonstrated also in non-human primates, but its effects in humans remain to be proven on a long-term basis. CR might be a very efficient anti-aging strategy but its definition and limits must be well understood before envisaging to apply it to human. In this review, we first report and compare the recently issued CR studies in non-human primates and… Expand

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References

SHOWING 1-10 OF 54 REFERENCES
Caloric restriction in humans: Potential pitfalls and health concerns
To date, the only intervention that has consistently been shown to slow the rate of aging, and to increase mean and maximum lifespan in short-lived species, is life-long calorie restriction. It isExpand
Caloric restriction improves health and survival of rhesus monkeys
TLDR
Comparisons of longitudinal data from two parallel studies of caloric restriction in rhesus monkeys confirm that health benefits of CR are conserved in monkeys and suggest that CR mechanisms are likely translatable to human health. Expand
Calorie restriction in humans: An update
TLDR
The effects of CR in non-obese humans on physiological parameters of energy metabolism and metabolic risk factors of age-associated disease in great detail are discussed. Expand
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
TLDR
A separation between health effects, morbidity and mortality, and similar to what has been shown in rodents, study design, husbandry and diet composition may strongly affect the life-prolonging effect of CR in a long-lived nonhuman primate is suggested. Expand
Recent advances in calorie restriction research on aging
TLDR
Several major issues related to CR's anti-aging mechanisms are discussed, including the importance of modulating deleterious chronic inflammation at molecular levels and the impact of epigenetic chromatin and histone modifications by CR at the ultimate control sites of gene expression. Expand
Promoting healthspan and lifespan with caloric restriction in primates
TLDR
Efforts should be made in combining nutrition-based clinical protocols with therapeutic and/or behavioral interventions to aim for synergetic effects, and therefore delay the onset of age-related diseases without adverse effects. Expand
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
TLDR
It is shown that CR significantly improves age-related and all-cause survival in monkeys on a long-term ~30% restricted diet since young adulthood, and indicates that the benefits of CR on ageing are conserved in primates. Expand
Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies
TLDR
This review focuses on the four methodological differences identified in a recent comparative report from the National Institute on Aging and University of Wisconsin nonhuman primate studies, namely feeding regimen, diet composition, age of onset, and genetics. Expand
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
TLDR
Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species. Expand
Do‐It‐Yourself Calorie Restriction: The Risks of Simplistically Translating Findings in Animal Models to Humans
  • É. Le Bourg, L. Redman
  • Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2018
TLDR
The two authors of the present article do not share the same view regarding the possible CR effect in humans, so it is important to express some statements about CR in humans to avoid any misinterpretation or inappropriate extrapolation of results. Expand
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2
3
4
5
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