Caloric restriction, longevity and aging: Recent contributions from human and non-human primate studies

@article{Pifferi2019CaloricRL,
  title={Caloric restriction, longevity and aging: Recent contributions from human and non-human primate studies},
  author={Fabien Pifferi and Fabienne Aujard},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2019},
  volume={95}
}
  • F. Pifferi, F. Aujard
  • Published 20 December 2019
  • Medicine, Biology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
View on Elsevier
doi.org
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References

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Caloric restriction in humans: Potential pitfalls and health concerns
Caloric restriction improves health and survival of rhesus monkeys
TLDR
Comparisons of longitudinal data from two parallel studies of caloric restriction in rhesus monkeys confirm that health benefits of CR are conserved in monkeys and suggest that CR mechanisms are likely translatable to human health.
Calorie restriction in humans: An update
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
TLDR
A separation between health effects, morbidity and mortality, and similar to what has been shown in rodents, study design, husbandry and diet composition may strongly affect the life-prolonging effect of CR in a long-lived nonhuman primate is suggested.
Recent advances in calorie restriction research on aging
Promoting healthspan and lifespan with caloric restriction in primates
TLDR
Efforts should be made in combining nutrition-based clinical protocols with therapeutic and/or behavioral interventions to aim for synergetic effects, and therefore delay the onset of age-related diseases without adverse effects.
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
TLDR
It is shown that CR significantly improves age-related and all-cause survival in monkeys on a long-term ~30% restricted diet since young adulthood, and indicates that the benefits of CR on ageing are conserved in primates.
Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies
TLDR
This review focuses on the four methodological differences identified in a recent comparative report from the National Institute on Aging and University of Wisconsin nonhuman primate studies, namely feeding regimen, diet composition, age of onset, and genetics.
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
TLDR
Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species.
Do‐It‐Yourself Calorie Restriction: The Risks of Simplistically Translating Findings in Animal Models to Humans
  • É. Le Bourg, L. Redman
  • Psychology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2018
TLDR
The two authors of the present article do not share the same view regarding the possible CR effect in humans, so it is important to express some statements about CR in humans to avoid any misinterpretation or inappropriate extrapolation of results.
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