Caloric restriction, longevity and aging: Recent contributions from human and non-human primate studies
@article{Pifferi2019CaloricRL, title={Caloric restriction, longevity and aging: Recent contributions from human and non-human primate studies}, author={Fabien Pifferi and Fabienne Aujard}, journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry}, year={2019}, volume={95} }
30 Citations
The Effects of Caloric Restriction and/or Intermittent Fasting on Bone Health
- MedicineJournal of Rehabilitation Therapy
- 2021
This mini-review summarizes the available information regarding the impact of caloric restriction (CR) and/ or intermittent fasting (IF) on bone health, highlighting areas of consistency and discrepancy and suggesting future areas of study to advance the understanding of CR and/or IF onBone health.
Overweight Management through Mild Caloric Restriction in Multigenerational Long-Tailed Macaque Breeding Groups
- BiologyVeterinary Sciences
- 2022
Mild CR targeted the right individuals, i.e., overweight adults, and had no adverse effects on the variables examined in this study, implying that mild CR can be a valuable overweight management strategy in group-housed NHPs.
Effect of Chronic Moderate Caloric Restriction on the Reproductive Function in Aged Male Wistar Rats
- BiologyNutrients
- 2022
It is suggested that beginning CR at the age of maturity reestablishes the behavioral sexual response and reproductive function in older animals after 6 months of CR and improves endocrine functioning during aging.
Extending lifespan by modulating the growth hormone/insulin-like growth factor-1 axis: coming of age
- BiologyPituitary
- 2021
Progress made in the years of aging research have allowed the opportunity to explore potential interventions to slow aging and extend healthy lifespan. Studies performed in yeast, worms, flies and…
Effectiveness of high cardiorespiratory fitness in cardiometabolic protection in prediabetic rats
- Medicine, BiologyMolecular medicine
- 2022
Either short-term caloric restriction or exercise followed by weight maintenance ameliorated cardiometabolic impairment in prediabetes, as indicated by increased insulin sensitivity, improved blood lipid profile, improved mitochondrial function and oxidative phosphorylation, reduced oxidative stress and inflammation, and improved cardiac function.
The marmoset as an important primate model for longitudinal studies of neurocognitive aging.
- Psychology, BiologyAmerican journal of primatology
- 2021
A longitudinal study of marmosets tested on reversal learning starting in middle-age found that, on average, the group ofMarmosets declined in cognitive performance around 8 years of age, however, highly variable patterns of cognitive aging trajectories across individuals were found.
Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging
- BiologyCell
- 2020
Molecular Mechanisms of Exercise and Healthspan
- MedicineCells
- 2022
The current evidence and opinions about regular exercise promoting healthspan through enhancing the functionality of the authors' organ systems and preventing diseases are reviewed.
Repurposing drugs to fight aging: The difficult path from bench to bedside
- Medicine, BiologyMedicinal research reviews
- 2020
Recent advances and challenges in the field of repurposing widely used conventional pharmaceuticals to target the aging process are summarized and discussed.
Aging and age‐related diseases: from mechanisms to therapeutic strategies
- Medicine, BiologyBiogerontology
- 2021
The status of aging research and the development of potential drugs for aging-related diseases, such as metformin, rapamycin, resveratrol, senolytics, as well as caloric restriction, are summarized.
References
SHOWING 1-10 OF 53 REFERENCES
Caloric restriction in humans: Potential pitfalls and health concerns
- Medicine, BiologyMechanisms of Ageing and Development
- 2006
Caloric restriction improves health and survival of rhesus monkeys
- Biology, MedicineNature communications
- 2017
Comparisons of longitudinal data from two parallel studies of caloric restriction in rhesus monkeys confirm that health benefits of CR are conserved in monkeys and suggest that CR mechanisms are likely translatable to human health.
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
- Medicine, BiologyNature
- 2012
A separation between health effects, morbidity and mortality, and similar to what has been shown in rodents, study design, husbandry and diet composition may strongly affect the life-prolonging effect of CR in a long-lived nonhuman primate is suggested.
Promoting healthspan and lifespan with caloric restriction in primates
- MedicineCommunications Biology
- 2019
Efforts should be made in combining nutrition-based clinical protocols with therapeutic and/or behavioral interventions to aim for synergetic effects, and therefore delay the onset of age-related diseases without adverse effects.
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
- Biology, MedicineNature communications
- 2014
It is shown that CR significantly improves age-related and all-cause survival in monkeys on a long-term ~30% restricted diet since young adulthood, and indicates that the benefits of CR on ageing are conserved in primates.
Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies
- BiologyThe journals of gerontology. Series A, Biological sciences and medical sciences
- 2017
This review focuses on the four methodological differences identified in a recent comparative report from the National Institute on Aging and University of Wisconsin nonhuman primate studies, namely feeding regimen, diet composition, age of onset, and genetics.
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
- Medicine, BiologyScience
- 2009
Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species.
Do‐It‐Yourself Calorie Restriction: The Risks of Simplistically Translating Findings in Animal Models to Humans
- PsychologyBioEssays : news and reviews in molecular, cellular and developmental biology
- 2018
The two authors of the present article do not share the same view regarding the possible CR effect in humans, so it is important to express some statements about CR in humans to avoid any misinterpretation or inappropriate extrapolation of results.