Calmodulin trapping by calcium-calmodulin-dependent protein kinase.

@article{Meyer1992CalmodulinTB,
  title={Calmodulin trapping by calcium-calmodulin-dependent protein kinase.},
  author={Tobias Meyer and Phyllis I Hanson and Lubert Stryer and Howard F Schulman},
  journal={Science},
  year={1992},
  volume={256 5060},
  pages={1199-202}
}
Multifunctional calcium-calmodulin-dependent protein kinase (CaM kinase) transduces transient elevations in intracellular calcium into changes in the phosphorylation state and activity of target proteins. By fluorescence emission anisotropy, the affinity of CaM kinase for dansylated calmodulin was measured and found to increase 1000 times after autophosphorylation of the threonine at position 286 of the protein. Autophosphorylation markedly slowed the release of bound calcium-calmodulin; the… CONTINUE READING
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