Calmodulin regulation of the cholinergic receptor in the rat heart during ontogeny and senescence

  title={Calmodulin regulation of the cholinergic receptor in the rat heart during ontogeny and senescence},
  author={A. Ho and K. Shang and R. Duffield},
  journal={Mechanisms of Ageing and Development},
The contents of calmodulin and cholinergic muscarinic receptor binding sites in the hearts of fetal, adult and aged rats have been examined. A biphasic pattern of calmodulin development was observed. A relatively high level of calmodulin appeared on gestational days 14-15 followed by a steady but significant decrease at birth and during the first week of postnatal life. The level of calmodulin then increased significantly during the first month followed by a decrease at 6 and 26 months of age… Expand
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  • A. Ho, R. Duffield
  • Biology, Medicine
  • Journal of molecular and cellular cardiology
  • 2000
Investigating whether there is a potential role played by the calcium-calmodulin processes in cardiac morphogenesis and malformations, especially in the development of cardiac hypertrophy found that 6-hydroxydopamine treatment on day 3 of incubation produced a dose-dependent increase in both heart and brain calmodulin levels. Expand
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Calmodulin regulation of cholinergic muscarinic receptor: effects of calcium and phosphorylating states.
  • A. Ho, J. Wang
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • 1985
Calmodulin regulation of cholinergic muscarinic receptor was investigated using synaptic membrane isolated from rat brains and [3H]-QNB as a binding ligand, showing both a Ca2+-dependent receptor loss and an increase depending on the state of membrane phosphorylation. Expand
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