Calmodulin regulation of cholinergic muscarinic receptor: effects of calcium and phosphorylating states.

@article{Ho1985CalmodulinRO,
  title={Calmodulin regulation of cholinergic muscarinic receptor: effects of calcium and phosphorylating states.},
  author={A. Ho and J. Wang},
  journal={Biochemical and biophysical research communications},
  year={1985},
  volume={133 3},
  pages={
          1193-200
        }
}
  • A. Ho, J. Wang
  • Published 1985
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
Calmodulin (CaM) regulation of cholinergic muscarinic receptor was investigated using synaptic membrane isolated from rat brains and [3H]-QNB as a binding ligand. CaM exerts a biphasic effect on receptor binding showing both a Ca2+-dependent receptor loss and an increase depending on the state of membrane phosphorylation. Calcineurin, a CaM-dependent protein phosphatase, mimicked the stimulatory effect of CaM in a dose-dependent manner. CaM-antagonists, W-7 and TFP reversed the stimulatory… Expand
18 Citations
Phosphorylation of brain muscarinic receptor: evidence of receptor regulation.
Calmodulin regulation of the cholinergic receptor in the rat heart during ontogeny and senescence
Characterization and regulation of a high affinity [3H]CNQX labelled AMPA receptor in rat neocortex.
...
1
2
...

References

SHOWING 1-10 OF 12 REFERENCES
A multifunctional calmodulin-stimulated phosphatase.
Mammalian brain phosphoproteins as substrates for calcineurin.
...
1
2
...