Calmodulin regulates the trafficking of KCNQ2 potassium channels.

  title={Calmodulin regulates the trafficking of KCNQ2 potassium channels.},
  author={Ainhoa Etxeberr{\'i}a and Paloma Aivar and Jose Angel Rodriguez-Alfaro and Alessandro Alaimo and Patricia Villac{\'e} and Juan Camilo G{\'o}mez-Posada and Pilar Areso and {\'A}lvaro Villarroel},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={22 4},
Voltage-dependent potassium KCNQ2 (Kv7.2) channels play a prominent role in the control of neuronal excitability. These channels must associate with calmodulin to function correctly and, indeed, a mutation (R353G) that impairs this association provokes the onset of a form of human neonatal epilepsy known as benign familial neonatal convulsions (BFNC). We show here that perturbation of calmodulin binding leads to endoplasmic reticulum (ER) retention of KCNQ2, reducing the number of channels that… CONTINUE READING


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