Calmodulin regulates the non-amyloidogenic metabolism of amyloid precursor protein in platelets.

@article{Canobbio2011CalmodulinRT,
  title={Calmodulin regulates the non-amyloidogenic metabolism of amyloid precursor protein in platelets.},
  author={Ilaria Canobbio and Silvia Catrical{\`a} and Cesare Balduini and Mauro Torti},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1813 3},
  pages={500-6}
}
A balance between the proteolytic processing of amyloid precursor protein APP through the amyloidogenic and the non-amyloidogenic pathways controls the production and release of amyloid β-protein, whose accumulation in the brain is associated to the onset of Alzheimer Disease. APP is also expressed on circulating platelets. The regulation of APP processing in these cells is poorly understood. In this work we show that platelets store considerable amounts of APP fragments, including sAPPα, that… CONTINUE READING

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