Calmodulin regulates the non-amyloidogenic metabolism of amyloid precursor protein in platelets.

  title={Calmodulin regulates the non-amyloidogenic metabolism of amyloid precursor protein in platelets.},
  author={I. Canobbio and S. Catrical{\`a} and C. Balduini and M. Torti},
  journal={Biochimica et biophysica acta},
  volume={1813 3},
  • I. Canobbio, S. Catricalà, +1 author M. Torti
  • Published 2011
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • A balance between the proteolytic processing of amyloid precursor protein APP through the amyloidogenic and the non-amyloidogenic pathways controls the production and release of amyloid β-protein, whose accumulation in the brain is associated to the onset of Alzheimer Disease. APP is also expressed on circulating platelets. The regulation of APP processing in these cells is poorly understood. In this work we show that platelets store considerable amounts of APP fragments, including sAPPα, that… CONTINUE READING
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