Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.

@article{iak2012CalmodulinKI,
  title={Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.},
  author={Mirza Ži{\vz}ak and Tiane Chen and Dorotea Bartoni{\vc}ek and Rafiquel Sarker and Nicholas C. Zachos and Boyoung Cha and Olga N Kovbasnjuk and Jelena Kora{\'c} and Sachin Mohan and Robert Reed Cole and Yueping Chen and Chung Ming Tse and Mark Donowitz},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 16},
  pages={
          13442-56
        }
}
The epithelial brush border (BB) Na(+)/H(+) exchanger 3 (NHE3) accounts for most renal and intestinal Na(+) absorption. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) inhibits NHE3 activity under basal conditions in intact intestine, acting in the BB, but the mechanism is unclear. We now demonstrate that in both PS120 fibroblasts and polarized Caco-2BBe cells expressing NHE3, CaMKII inhibits basal NHE3 activity, because the CaMKII-specific inhibitors KN-93 and KN-62 stimulate NHE3… CONTINUE READING
BETA

Similar Papers

Loading similar papers…