Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5.

Abstract

Metabotropic glutamate receptors (mGluRs) 1-8 are G protein-coupled receptors (GPCRs) that modulate excitatory neurotransmission, neurotransmitter release, and synaptic plasticity. PKC regulates many aspects of mGluR function, including protein-protein interactions, Ca(2+) signaling, and receptor desensitization. However, the mechanisms by which PKC… (More)
DOI: 10.1073/pnas.0712033105

Topics

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