Calmodulin-dependent protein kinase II triggers mouse egg activation and embryo development in the absence of Ca2+ oscillations.

@article{Knott2006CalmodulindependentPK,
  title={Calmodulin-dependent protein kinase II triggers mouse egg activation and embryo development in the absence of Ca2+ oscillations.},
  author={Jason Glenn Knott and Allison J Gardner and Suzanne Madgwick and Keith T Jones and Carmen J Williams and Richard M Schultz},
  journal={Developmental biology},
  year={2006},
  volume={296 2},
  pages={388-95}
}
Fertilization in mammalian eggs is accompanied by oscillatory changes in intracellular Ca(2+) concentration, which are critical for initiating and completing egg activation events and the developmental program. Ca(2+)/Camodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is postulated to be the downstream transducer of the Ca(2+) signal in many cell types. We tested the hypothesis that CaMKII is the major integrator of Ca(2+)-induced egg activation events and embryo… CONTINUE READING
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