Calmodulin-dependent kinase II regulates Dlx5 during osteoblast differentiation.

  title={Calmodulin-dependent kinase II regulates Dlx5 during osteoblast differentiation.},
  author={Jae Hee Seo and Yongdong Jin and Hyung Min Jeong and Yeon-Jin Kim and Hye Gwang Jeong and C. S. Yeo and Kwang Youl Lee},
  journal={Biochemical and biophysical research communications},
  volume={384 1},
Calmodulin-dependent kinase II (CaMKII) acts as a key regulator of osteoblast differentiation. CaMKII is a Ca(2+)-activated serine/threonine kinase and it regulates the activity of target proteins by phosphorylation. Dlx5 transcription factor plays crucial roles in osteoblast differentiation. The expression of Dlx5 is regulated by several osteogenic signaling pathways from early stages of osteoblastogenesis. In addition, Dlx5 can be phosphorylated and activated by p38, suggesting that the… CONTINUE READING


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