Calmodulin controls adaptation of mechanoelectrical transduction by hair cells of the bullfrog's sacculus.

@article{Walker1996CalmodulinCA,
  title={Calmodulin controls adaptation of mechanoelectrical transduction by hair cells of the bullfrog's sacculus.},
  author={Roderick G. Walker and A. J. Hudspeth},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 5},
  pages={2203-7}
}
Deflection of the mechanically sensitive hair bundle atop a hair cell opens transduction channels, some of which subsequently reclose during a Ca2+-dependent adaptation process. Myosin I in the hair bundle is thought to mediate this adaptation; in the bullfrog's hair cell, the relevant isozyme may be the 119-kDa amphibian myosin I beta. Because this molecule resembles other forms of myosin I, we hypothesized that calmodulin, a cytoplasmic receptor for Ca2+, regulates the ATPase activity of… CONTINUE READING
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Walker and Hudspeth Proc

  • R. E. Cheney, M. A. Riley, Mooseker, 24 M.S.CellMotil.Cytoskel., 215–223. Neurobiology
  • Natl. Acad. Sci. USA 93
  • 1996
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