Calmodulin binds to the cytoplasmic domain of angiotensin-converting enzyme and regulates its phosphorylation and cleavage secretion.

@article{Chattopadhyay2005CalmodulinBT,
  title={Calmodulin binds to the cytoplasmic domain of angiotensin-converting enzyme and regulates its phosphorylation and cleavage secretion.},
  author={Saurabh Chattopadhyay and Kizhakkekara R Santhamma and Saubhik Sengupta and Brian McCue and Michael Kinter and Ganes C Sen and Indira Sen},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 40},
  pages={33847-55}
}
The rate of cleavage secretion of the enzymatically active ectodomain of angiotensin-converting enzyme (ACE) is regulated by tyrosine phosphorylation of the protein and by the phorbol ester, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C. Here, we report that both calmodulin inhibitor (CaMI) and calmodulin kinase inhibitor could also enhance cleavage secretion of ACE. This effect was accompanied by the dissociation of calmodulin from a specific region within the… CONTINUE READING